Functional VEGF and VEGF receptors are expressed in human medulloblastomas
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چکیده
منابع مشابه
VEGF and EG-VEGF
Vascular endothelial growth factor (VEGF) plays an essential role in angiogenesis. This includes developmental angiogenesis as the loss of a single allele is embryonic lethal due to lack of development of endothelial cells. During early development, endothelial cells depend on VEGF for survival and if it is withdrawn, massive apoptosis results. This is not true in adult organisms; withdrawal of...
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PURPOSE The vascular endothelial growth factor (VEGF) family is involved in vascular leakage and angiogenesis in diabetic retinopathy (DR) in the eye, but may also have physiological functions. Based on the hypothesis that differential VEGF receptor (VEGFR) expression in the retina is an important determinant of effects of VEGF, this study was conducted to investigate VEGFR expression in the di...
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Background Establishment of viable pregnancy requires embryo implantation and placentation. Ectopic pregnancy (EP) is a pregnancy complication which occurs when an embryo implants outside of the uterine cavity, most often in a fallopian tube. On the other hand, an important aspect of successful implantation is angiogenesis. Vascular endothelial growth factor (VEGF) is a potent angiogenic factor...
متن کاملVEGF, its receptors and the tie receptors in recurrent miscarriage.
The aetiology of recurrent miscarriage (at least three consecutive miscarriages) usually remains unsolved. The vascular endothelial growth factor (VEGF) family of proteins, together with their receptors and the Tie (tyrosine kinase with immunoglobulin and epidermal growth factor homology domains) receptors, are crucial for embryonic development. Therefore, we used immunohistochemistry to analys...
متن کاملCoexpression of VEGF receptors VEGF-R2 and neuropilin-1 in proliferative diabetic retinopathy.
PURPOSE To elucidate vascular endothelial growth factor (VEGF)-mediated pathogenesis of fibrovascular proliferation in diabetic retinopathy. METHODS Fibrovascular tissues were obtained at vitrectomy from 22 cases with proliferative diabetic retinopathy. The half-divided tissues were processed for reverse transcription-polymerase chain reaction (RT-PCR) analysis to examine the expression of VE...
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ژورنال
عنوان ژورنال: Neuro-Oncology
سال: 2007
ISSN: 1523-5866,1522-8517
DOI: 10.1215/15228517-2007-032